Continuous Flow Process Development for a Radical Chlorodifluoromethylation Reaction

Time: 12:45 pm
day: Day Two Track A AM


• Development of a flow process for a fast exothermic reaction with thermally unstable

reactants and a product prone to decomposition

• Further optimization of the flow process was completed in a second-generation process to

avoid reactor fouling issues

• The first-and second-generation processes were successfully scaled-up in a GMP facility

at the multi-kilogram scale