Continuous Flow Process Development for a Radical Chlorodifluoromethylation Reaction
Time: 12:45 pm
day: Day Two Track A AM
Details:
• Development of a flow process for a fast exothermic reaction with thermally unstable
reactants and a product prone to decomposition
• Further optimization of the flow process was completed in a second-generation process to
avoid reactor fouling issues
• The first-and second-generation processes were successfully scaled-up in a GMP facility
at the multi-kilogram scale